Four-strand DNA structure found in cells : Nature News & Comment: "G-quadruplex visualized
This seems likely to be the case, Balasubramanian and colleagues found. They engineered an antibody that binds tightly and specifically to G-quadruplex structures and does not bind to double-stranded helical DNA. When they incubated the antibody with human cells in culture, they found that it bound to many different sites in the chromosomes, only around a quarter of them in telomeres.
“It’s early days, but if we can map exactly where these G-quadruplex structures pop up in the genome, we may learn how better to control genes or other cellular processes that go awry in diseases like cancer,” he says. “That’s the long-term vision anyway.’’
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