S3InfiDisk for EC2 - A distributed caching system for EC2 with backend storage on S3.
This is a really interesting concept, and is going to be really useful for deploying applications on EC2. Right now, it's a little tricky, because each EC2 node isn't persistant, so you have to store all your permanent data on S3.
Now, we need something like this to be GPLed, and perhaps something more like Gluster, so that we could use those huge 160GB disks on each EC2 instance for fast access and caching, and then use S3 for permanent storage.